9-amino-1, 4 ethano-1, 2, 3, 4-tetrahydroacridine and...

Details 9-amino-1, 4 ethano-1, 2, 3, 4-tetrahydroacridine and... 9-amino-1, 4 ethano-1, 2, 3, 4-tetrahydroacridine and...

C - Chemistry, Metallurgy

07

D

167/227

C07D 219/10 (2006.01) A61K 31/473 (2006.01) C07C 251/24 (2006.01) C07D 221/22 (2006.01)

Patent

CA 1341335

There are disclosed compounds having the formula (see formula I) wherein R is hydrogen, loweralkyl or loweralkylcarbonyl; R1 is hydrogen, loweralkyl, loweralkylcarbonyl, aryl, diloweralkylaminoloweralkyl, arylloweralkyl, diarylloweralkyl, oxygen-bridged arylloweralkyl or - oxygen-bridged diarylloweralkyl; R2 and R3 are independently H or CH3; X is hydrogen, loweralkyl, cycloalkyl, loweralkoxy, halogen, hydroxy, nitro, trifluoromethyl, formyl, loweralkylcarbonyl, aryl carbonyl, -SH, loweralkylthio, -NHCOR4 or -NR5R6 where R4 is hydrogen or loweralkyl, and R5 and R6 are independently hydrogen, loweralkyl or cycloalkyl; Y and Z are independently a direct bond, CR7R8 or CR7R8-CR9R10; and Q' and Q are independently CR7'R8', CR7'R8'-CR9'R10' or CR7'R8'-CR9'R10'-CR11R12, where each of R7 through R12 and R7 through R10' is independently H or CH3; stereo, optical and geometrical isomers thereof, and pharmaceutically acceptable acid addition salts thereof, which are useful for enhancing memory.

558816

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