9-amino-podophyllotoxin derivatives, method for the...

C - Chemistry – Metallurgy – 07 – D

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C07D 493/04 (2006.01) A61K 31/36 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2546823

The invention relates to compounds of formula (I), wherein R¿1? is a group selected from hydrogen, alkyl, aryl, aryalkil, heteroaryl, heteroarylalkyl, alkylcarbonyl, arylcarbonyl, arylalkylcarbonyl, alkoxycarbonyl, aryloxycarbonyl, arylalkoxycarbonyl, heterocycloalkoxycarbonyl, alkylsulfonyl, arylsulfonyl, arylalkylsulfonyl, phosphonic and Si(Ra)¿2?R¿b?, Y is a group selected from HN-NH and N-R¿2?, R¿3? is a hydrogen atom, an alkyl, cycloalkyl, aryl, arylalkyl group, R¿4? is hydrogen atom or an alkyl group, enantiomers, diastereoisomers and the salts thereof.

Composés de formule (I) dans laquelle R1 représente un groupement choisi parmi hydrogène, alkyle, aryle, arylalkyle, hétéroaryle, hétéroarylalkyle, alkylcarbonyle, arylcarbonyle, arylalkylcarbonyle, alkoxycarbonyle, aryloxycarbonyle, arylalkoxycarbonyle, hétérocycloalkoxycarbonyle, alkylsulfonyle, arylsulfonyle, arylalkylsulfonyle, phosphonique et Si(Ra)2Rb, Y représente un groupement choisi parmi HN-NH et N-R2, R3 représente un atome d'hydrogène, un groupement alkyle, cycloalkyle, aryle, arylalkyle, R4 représente un atome d'hydrogène ou un groupement alkyle, leurs énantiomères, diastéréoisomères ainsi que leurs sels d'addition à un acide ou à une base pharmaceutiquement acceptable. Médicaments.

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