9-aminoalkyl-9,10-dihydro-9,10-methano-anthracene derivatives

C - Chemistry – Metallurgy – 07 – D

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260/595.2, 260/2

C07D 295/02 (2006.01) C07C 47/235 (2006.01) C07C 47/238 (2006.01) C07C 47/453 (2006.01) C07C 57/50 (2006.01) C07C 61/39 (2006.01) C07D 295/03 (2006.01) C07D 295/125 (2006.01)

Patent

CA 1061787

9-Aminoalkyl-9,10-dihydro-9,10-methano-Anthracene Derivatives Abstract of the Disclosure Novel 9-aminoalkyl-methanoanthracenes of the formula: Image wherein A is C1-C4 alkylene or C3-C4 alkenylene and R1 and R2 are each hydrogen, C1-C4 alkyl, C3-C4 alkenyl, C3-C4 alkynyl, cyclo- propyl (C1-C3) alkyl, phenyl (C1-C3) alkyl or polyhalo (C2-C4) alkyl or, when taken together with the adjacent nitrogen atom, they may form a nitrogen-containing heterocyclic ring selected from the group consisting of pyrrolidino, piperidino and morpholino; and their non-toxic salts, which are useful as anti-anxiety, anti-depressant, major tranquilizer, anti-histamine and anti-allergy drugs and can be prepared through a novel key intermediate, i.e. 9-formyl-9,10-dihydro-9-10-methano- anthracene, by various methods.

241665

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