C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 219/10 (2006.01) A61K 31/47 (2006.01) C07D 261/20 (2006.01) C07F 7/08 (2006.01) C07F 7/10 (2006.01) C07F 7/12 (2006.01)
Patent
CA 2061084
Abstract HOE 91/S 005 9-Aminotetrahydroacridines and related compounds, a process for their preporation and their use as medicaments The present invention relates to 9-amino-1,2,3,4-tetrahydroacridines and related compounds of formula 1 Image wherein Y ix C=0 or CHOH;R1 is hydrogen or loweralkyl; R2 is hydrogen, loweralkyl, or phenylloweralkyl; R3 is hydrogen, OR4 wherein R4 is hydrogen or COR5 wherein R5 is loweralkyl, X is hydrogen, loweralkyl, halogen,loweralkoxy, hydroxy, or trifluoromethyl, the geometric or optical isomers thereof, N-oxides, thereof, or the pharmaceutically acceptable acid addition salts thereof, which are useful in relieving memory dysfunction and are thus indicated in the treatment of Alzheimer's diease. The inventionrelates further to a process for the preparation of the above compounds.
Kapples Kevin James
Shutske Gregory Michael
Tomer John Dick
Aventis Pharmaceuticals Inc.
Bereskin & Parr
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