C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/235.01
C07D 309/12 (2006.01) C07C 405/00 (2006.01)
Patent
CA 1223871
Abstract Tne invention relates to compounds of Formula I (I) , Image wherein the 9-bromine atom can be in the .alpha.- or .beta.-position, R1 is the residue CH2OH or Image where R2 means a hydrogen atom or an alkyl, cycloalkyl, aryl, or heterocyclic residue; or R1 is the residue Image where R3 means an acid residue or the residue R2; and A is a -CH2-CH2- or cis-CH=CH-group, B is a -CH2-CH2-, a trans-CH=CH-, or a -C?C-group, W is a free or functionally modified hydroxy- methylene group or a free or functionally modified ? group wherein the OH-group can be in the .alpha.- or .beta.- position, D and E together mean a direct bond or D is a straight-chain, branched-chain, or cyclic alkylene group of 1-10 carbon atoms optionally substituted by fluorine atoms, and E is an oxygen or sulfur atom, a direct bond, a -C?C-bond, or a -CR6=CR7-group wherein R6 and R7 are different from each other and represent a hydrogen atom, a chlorine atcm, or a C1-C4-alkyl group, R4 is a free or functionally modified hydroxy group, R5 is a hydrogen atom, an alkyl group, a halo- substituted alkyl group, a cycloalkyl group, an optionally substituted aryl group, or a heterocyclic group; and, if R2 means a hydrogen atom, the salts thereof with physiologically compatible bases, their preparation, and their use, for example, as abortifacients. .1.
416964
Elger Walter
Raduchel Bernd
Schwarz Norbert
Skuballa Werner
Vorbruggen Helmut
Marks & Clerk
Schering Aktiengesellschaft
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