9-deazaguanines

Details 9-deazaguanines 9-deazaguanines

C - Chemistry, Metallurgy

07

D

167/220, 260/242

C07D 487/04 (2006.01) A61K 31/505 (2006.01) C07D 239/46 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01)

Patent

CA 1293727

BPC0500887 PD-3557-Cl ABSTRACT The present invention is novel derivatives of pyrrolo[3,2-d]pyrimidines and pharmaceutical compositions and methods of use therefor. The derivatives are inhibitors of purine nucleoside phosphorylase selectively cytotoxic to T-cells but not to B-cells in the presence of 2'-deoxyguanosine and, therefore, are for use in the treatment of autoimmune diseases, gout, psoriasis or rejection of transplantation.

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