C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 305/14 (2006.01) C07D 405/12 (2006.01) C07D 407/12 (2006.01) C07F 7/10 (2006.01) C07K 5/04 (2006.01)
Patent
CA 2182103
Compounds having formula (I), wherein -OR1 comprises alkanoyl or the C-13 side-chain of paclitaxel; R2, R3, and R6 can be oxygenated or hydrogen in various combination; and R4 and R5 are acyl groups, as well as a process for thepreparation thereof, pharmaceutical compositions containing the above compounds and a method for their use in inhibiting tumor growth.
L'invention concerne des composés ayant la formule (I). Dans cette formule, -OR<1> est un groupe alcanoyle ou la chaîne latérale en position C-13 de la molécule de paclitaxel; R<2>, R<3> et R<6> peuvent être des groupes oxygénés ou il peut s'agir d'hydrogènes, combinés de différentes manières; et R<4> et R<5> sont des groupes acyle. L'invention concerne également un procédé de préparation des composés en question, des compositions pharmaceutiques les contenant et leur utilisation pour inhiber la croissance de tumeurs.
Klein Larry L.
Li Leping
Yeung Clinton M.
Abbott Laboratories
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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