9-halogen-11beta-hydroxy-prostaglandin derivatives, process...

Details 9-halogen-11beta-hydroxy-prostaglandin derivatives, process... 9-halogen-11beta-hydroxy-prostaglandin derivatives, process...

C - Chemistry, Metallurgy

07

C

C07C 405/00 (2006.01) A61K 31/557 (2006.01) C07D 213/63 (2006.01) C07D 257/04 (2006.01) C07D 307/58 (2006.01) C07D 333/32 (2006.01)

Patent

CA 2073462

Abstract The invention relates to 9-halogen-11.beta.-hydroxy-prostane derivatives of formula I Image (I), in which Z means the radicals Image or Image , Hal means an .alpha.- or .beta.-position chlorine or fluorine atom, R1 means the radical CH2OH or Image with R2 meaning a hydrogen atom, an alkyl, cycloalkyl, aryl or heterocyclic radical or R1 means the radical Image with R3 meaning an acid radical or radical R2 and R4 means a cycloalkyl group, and if R2 has the meaning of a hydrogen atom, its salts with physiologically compatible bases and its cyclodextrin clathrates, process for their production and their pharmaceutical use.

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