9-halogen prostaglandins

Details 9-halogen prostaglandins 9-halogen prostaglandins

C - Chemistry, Metallurgy

07

D

260/235.01

C07D 307/42 (2006.01) C07C 405/00 (2006.01) C07D 213/63 (2006.01)

Patent

CA 1251201

ABSTRACT OF THE DISCLOSURE 9-Halogen prostane derivatives of formula I Image (I), wherein Hal is a chlorine or fluorine atom in the .alpha. or .beta. - position, R1 is the radical CH20H or -C-OR2 with R2 is a hydrogen atom, an alkyl, cycloalkyl, aryl or heterocyclic radical or R1 is the radical Image , with R3 is an acid radical or the radical R2 A is a -CH2-CH2-, a trans-CH=CH- or a -C?C- group, W is a free functionally modified hydroxymethylene group or a free or func- tionally modified Image group, whereln the OH group may be in the .alpha. or .beta. -position, D and E together form a direct bond or D is a straight-chain, branched-chain or cyclic alkylene group wtth 1 to 10 C-atoms, which may be substituted by fluorine atoms, E represents an oxy- gen or sulfur atom, a direct bond, a -C?C- bond or a -CR6=CR7- group, where R6 and R7 are different and are a hydrogen atom, a chlorine atom or a C1-C4-alkyl group, R4 a free or functionally modified hydroxy group, and R5 is a hydrogen atom, an alkyl, an alkenyl, a halogen-substituted alkyl, a cycloalkyl, an aryl or a heterocyclic group or when D and E forms a direct bond an alkenyl group and, where R2 is a hydrogen atom, its salts with physiolog- ically tolerable bases useful as pharmaceuticals having compound effects over material prostaglandins.

478989

Affiliated with

Also associated with

Rating

9-halogen prostaglandins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 9-halogen prostaglandins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 9-halogen prostaglandins will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1326794