9-hydroxyalkoxyguanines

Details 9-hydroxyalkoxyguanines 9-hydroxyalkoxyguanines

C - Chemistry, Metallurgy

07

D

167/220, 260/242

C07D 473/00 (2006.01) A61K 31/52 (2006.01) C07D 233/90 (2006.01) C07D 239/50 (2006.01) C07D 473/16 (2006.01) C07D 473/18 (2006.01) C07D 473/32 (2006.01)

Patent

CA 1296726

Abstract Compounds of formula (I), and a pharmaceutically acceptable salts thereof: Image (I) wherein: R1 is hydrogen or CH2OH; R2 is hydrogen or, (when R1 is hydrogen), hydroxy or CH2OH; R3 is CH2OH or, (when R1 and R2 are both hydrogen), CH(OH)CH2OH; R4 is hydrogen, hydroxy, amino or OR5 wherein R5 is C1-6 alkyl, phenyl or phenyl C1-2 alkyl either of which phenyl moieties may be substituted by one or two halo, C1-4 alkyl or C1-4 alkoxy groups; and in which any OH groups in R1, R2 and/or R3 may be in the form of O-acyl, phosphate, cyclic acetal or cyclic carbonate derivatives thereof; having antiviral activity, processes and intermediates for their preparation and their use as pharmaceuticals.

525073

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