9-n-ethenyl derivatives of 9(s)-erythromycylamine

Details 9-n-ethenyl derivatives of 9(s)-erythromycylamine 9-n-ethenyl derivatives of 9(s)-erythromycylamine

C - Chemistry, Metallurgy

07

H

C07H 17/08 (2006.01) A61K 31/70 (2006.01)

Patent

CA 2217417

The invention relates to 9-N-ethenyl derivatives of 9(S)-erythromycylamine, new semisynthetic antibiotics of the macrolide class of the general formula (I) (See Formula I) wherein R1 and R2 are the same or different and represent nitryl, a carboxyl group of the formula COOR3, wherein R3 represents a C1-C4 alkyl group, or a keto group of the formula COR4, wherein R4 represents a C1-C4 alkyl group, to their pharmaceutically acceptable addition salts with inorganic or organic acids, to a process for their preparation, to a process for the preparation of the pharmaceutical compositions as well as to the use of the obtained pharmaceutical compositions in the treatment of bacterial infections.

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