9-purinyl phosphonic acid derivatives

Details 9-purinyl phosphonic acid derivatives 9-purinyl phosphonic acid derivatives

C - Chemistry, Metallurgy

07

F

C07F 9/6561 (2006.01) A61K 31/675 (2006.01)

Patent

CA 2045783

This invention relates to novel purine nucleoside phosphorylase inhibitors of the formula: (see formula I) the tautomeric forms thereof, and the pharmaceutically acceptable salts thereof, wherein (see formula II) with Ar being a bridging moiety to which its adjacent CH2 moiety is bonded to one ring carbon atom and the Z moiety is bonded to a second ring carbon atom of an R9-substituted phenyl, thiophene or furan moiety, Z is a moiety of sub- types (a), (b), (c), (d), or (e) wherein (see formulas a, b, c, d, e) to the methods and intermediates for their preparation and to their use as immunosuppressants, antilymphoma, antileu- kemic, antiviral and antiprotozoal agents.

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