9-substituted 8-oxoadenine compound

Details 9-substituted 8-oxoadenine compound 9-substituted 8-oxoadenine compound

C - Chemistry, Metallurgy

07

D

C07D 473/18 (2006.01) A61K 31/522 (2006.01) A61K 31/5377 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01) A61P 37/08 (2006.01)

Patent

CA 2559036

An 8-oxoadenine compound represented by the formula (1): [wherein ring A represents a 6- to10-membered aromatic carbocycle, etc.; R represents halogeno, alkyl, etc.; n is an integer of 0 to 2; Z1 represents alkylene; X2 represents oxygen, sulfur, SO2, NR5, CO, CONR5, NR5CO, etc.; Y1, Y2, and Y3 each independently represents a single bond or alkylene; X1 represents oxygen, sulfur, NR4 (wherein R4 represents hydrogen or alkyl), or a single bond; R2 represents (un)substituted alkyl, etc.; and R1 represents hydrogen, hydroxy, alkoxy, alkoxycarbonyl, haloalkyl, etc.] or a pharmaceutically acceptable salt thereof. They have immunoregulatory activity such as interferon-inducing activity and are useful as an antiviral agent, antiallergic, etc.

Il est prévu un composé 8-oxoadénine représenté par la formule (1) : (1) [où l~anneau A représente un carbocycle aromatique de 6 à 10 membres, etc. ; R représente un halogéno, un alkyle, etc. ; n est un entier de 0 à 2 ; Z?1¿ représente un alkylène; X représente de l~oxygène, du soufre, SO¿2?, NR?5¿, CO, CONR?5¿, NR?5¿CO, etc.; Y?1¿, Y , et Y?3¿ représentent chacun indépendamment une simple liaison ou un alkylène ; X?1¿ représente de l~oxygène, du soufre, NR?4¿ (où R?4¿ représente de l~hydrogène ou un alkyle), ou une simple liaison; R représente un alkyle (in)substitué, etc. ; et R?1¿ représente de l~hydrogène, un hydroxy, un alkoxy, un alkoxycarbonyle, un haloalkyle, etc.] ou un sel acceptable pharmaceutiquement de ceux-ci. Ils ont une activité immunorégulatrice comme une activité induisant l~interféron et servent d~agent antiviral, antiallergique, etc.

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