C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 237/26 (2006.01) A61K 31/65 (2006.01) C07C 311/08 (2006.01) C07C 311/21 (2006.01) C07D 213/79 (2006.01) C07D 307/68 (2006.01) C07D 333/26 (2006.01)
Patent
CA 2183565
This invention relates to compounds of formula (I) wherein R1 is hydrogen or - CH2NR5R6; R2 is hydrogen or R4(CH2)nCO-; n is an integer from 0 to 4; R3 is R8(CH2)mCO- or R8(CH2)mSO2-; m is an integer from 0 to 4; R4, R5, R6 and R8 are defined as in the specification and the pharmaceutically acceptable salts of such compounds. Compounds of formula (I) exhibit antibiotic activity against a wide range of gram-positive and gram-negative organisms, including organisms that are resistant to tetracycline antibiotics.
L'invention porte sur des composés de formule (I), dans laquelle R?1¿ représente hydrogène ou -CH¿2?NR?5¿R?6¿; R?2¿ représente hydrogène ou R?4¿(CH¿2?)¿n?CO-; n est un nombre entier choisi entre 0 et 4; R?3¿ représente R?8¿(CH¿2?)¿m?CO- ou R?8¿(CH¿2?)¿m?SO¿2?-; m est un nombre entier choisi entre 0 et 4; R?4¿, R?5¿, R?6¿ et R?8¿ sont définis dans la description, et sur les sels acceptables sur le plan pharmaceutique desdits composés. Les composés de formule (I) possèdent une activité antibiotique contre une grande variété d'organismes gram-positifs et gram-négatifs, dont des organismes résistants aux antibiotiques de type tétracycline.
Su Wei-Guo
Pfizer Inc.
Smart & Biggar
LandOfFree
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