9-(substituted thio)-4h-pyrido[1,2-a]-pyrimidin-4-one...

Details 9-(substituted thio)-4h-pyrido[1,2-a]-pyrimidin-4-one... 9-(substituted thio)-4h-pyrido[1,2-a]-pyrimidin-4-one...

C - Chemistry, Metallurgy

07

D

167/219, 260/242

C07D 471/04 (2006.01) A61K 31/505 (2006.01)

Patent

CA 1283411

ABSTRACT OF THE DISCLOSURE 9-(Substituted thio)-4H-pyrido[1,2-a]pyrimidin- 4-one derivatives of the formula: Image (I) (wherein n is 0 or 1, R is -COR1, -CONR4R5 or -CH2R6, R1 is C1-C5 alkyl, C3-C7 cycloalkyl, allylthio, styryl, phenoxymethyl, thienylmethyl, C6-C10 aryl optionally substituted, benzyl optionally substituted or 5- or 6-membered heterocyclic group optionally substituted, R2 and R3 each is hydrogen, C1-C5 alkyl, carboxy, C2-C6 alkoxycarbonyl or benzyloxycarbonyl optionally substituted, R4 and R5 each is hydrogen, C1-C5 alkyl, C3-C7 cycloalkyl or phenyl optionally substituted, and R6 is pyridyl or phenyl optionally substituted) being useful as antiulcer agents are provided through several routes.

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