9-thiomaytansinoids, their production and use

Details 9-thiomaytansinoids, their production and use 9-thiomaytansinoids, their production and use

C - Chemistry, Metallurgy

07

D

260/237.1, 260/2

C07D 498/18 (2006.01)

Patent

CA 1169423

Abstract of the Disclosure Novel 9-thiomaytansinoid compounds represented by the formula Image (I) wherein R is hydrogen or acyl derived from a carboxylic acid, X is chlorine or hydrogen, Y is hydrogen, lower alkylsulfonyl, or alkyl or aralkyl which are unsubstituted or substituted are disclosed, as well as methods for their production. The compounds (I) are useful as antitumor, antiprotozoal and anti- fungal agents.

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