99 mtc (iii) myocardial imaging agents which are...

Details 99 mtc (iii) myocardial imaging agents which are... 99 mtc (iii) myocardial imaging agents which are...

C - Chemistry, Metallurgy

07

F

260/210, 167/48,

C07F 13/00 (2006.01) A61K 51/04 (2006.01) C07H 23/00 (2006.01)

Patent

CA 1300608

99mTc(III) MYOCARDIAL IMAGING AGENTS WHICH ARE NON-REDUCABLE IN VIVO Abstract A cationic 99mTcIII myocardial imaging agent: is disclosed which has a relatively negative redox potential. Thiq prevents in vivo reduction of the Tc(III) to Tc(II). The redox potential of the Tc(III) is controlled by complexing the Tc with both hard and soft atoms. Preferably four of the atoms complexed to the Tc(III) are hard atoms such as nitrogen or oxygen and the remaining two are soft atoms such as phos- phorous or arsenic. These imaging agents are particu- larly useful in imaging the human heart.

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