C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/14 (2006.01) A61K 31/4375 (2006.01) A61K 35/00 (2006.01) C07D 207/34 (2006.01) C07D 213/24 (2006.01)
Patent
CA 2756152
The invention relates to novel 9H-pyrrolo[2,3-b: 5,4-c'] dipyridine azacarbolines of formula (I), where: Z2, Z3, and Z4 are CH, CRa, CRs, or N; R3 is H, Hal; CF3, CHF2; OH, alkoxy; NH2, NH (alkyl), N(alkyl)2; C(O)O alkyl; CONH(alkyl), CON(alkyl)2; C1-C10 alkyl; aryl; heteroaryl; R6 is heteroaryl; Ra is CONH2, CONH alkyl, CONH cycloalkyl; CONH heterocycloalkyl; CON(alkyl)2; CON(alkyl)(heterocycloalkyl); CONHN(alkyl)2; C(O)heterocycloalkyl; Rs is H; Hal, OH; O-alkyl(C1-C10); NH2; N(alkyl(C1-C10) or cycloalkyl(C3-C7))2; NHC(O)R3a; N(alkyl(C1-C10)C(O)R3a; NHS(O2)R3a; N(alkyl(C1-C10)S(O2)R3a; CO2R3a; SR3a; S(O)R3a; S(O2)R3a; Ra and Rs optionally form a cycle; R3a is selected from among Hal, CF3, C1-C10 alkyl; C3-C7 cycloalkyl; C2-C6 alkenyl; C2-C6 alkynyl; OH; O-alkyl(C1-C10); (C3-C7); heterocycloalkyl (C3-C7); NH2; NH-(alkyl(C1-C10) or cycloalkyl(C3-C7)); N(alkyl(C1-C10) or cycloalkyl(C3-C7))2; NH-(alkyl(C1-C10) or heterocycloalkyl(C3-C7)); N(alkyl(C1-C10) or heterocycloalkyl(C3-C7))2, as well as to the isomers and salts of said substances of formula (I) and to the therapeutic use thereof for treating cancer.
Nouvelles azacarbolines 9H-pyrrolo [2,3-b:5,4-c']dipyridine de formule (I) : avec Z2, Z3, Z4 représentent CH, CRa, CRs ou N; R3 représente H, HaI; CF3, CHF2;OH, alkoxy;NH2, NH(alkyle), N(alkyle)2; C(O)Oalkyle; C0NH(alkyle),C0N(alkyle)2; C1 -C10 alkyle; aryle; hétéroaryle; R6 représente hétéroaryle; Ra représente CONH2, CONHalkyle,CONHcycloalkyle; CONHhétérocycloalkyle; CON(alkyle)2; CON(alkyle)(hétérocycloalkyle); CONHN(alkyle)2; C(O)hétérocycloalkyle; Rs représente H;Ha1, OH; 0-alkyle(C1 - C10); NH2; N(alkyle(C1 -C10) ou cycloalkyle(C3-C7))2; NHC(O)R3a; N(alkyle(C1 - C10)C(O)R3a; NHS(O2)R3a; N(alkyle(C1 -C10)S(O2)R3a; CO2R3a; SR3a; S(O)R3a;S(O2)R3a; Ra et Rs forment éventuellement un cycle; ??R3a étant choisi parmi HaI, CF3, C1 -C10 alkyle; C3- C7 cycloalkyle; C2-C6 alkenyle; C2-C6 alkynyle; OH; O-alkyle(C1 -C10); (C3-C7); hétérocycloalkyle (C3-C7); NH2; NH- (alkyle(C1 -C10) ou cycloalkyle(C3-C7)); N(alkyle(C1 -C10) ou cycloalkyle(C3-C7))2; NH-(alkyle(C1 -C10) ou hétérocycloalkyle (C3-C7)); N(alkyle(C1 -C10) ou hétérocycloalkyle (C3-C7))2; ainsi que les isomères et sels desdits produits de formule (I) et leur application en thérapeutique pour le traitement du cancer.
Babin Didier
Bedel Olivier
Gouyon Thierry
Mignani Serge
Papin David
Robic
Sanofi
LandOfFree
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