A 12-membered ring macrolide active substance

Details A 12-membered ring macrolide active substance A 12-membered ring macrolide active substance

C - Chemistry, Metallurgy

12

P

C12P 17/16 (2006.01) A61K 31/365 (2006.01) A61K 31/4025 (2006.01) A61K 31/4523 (2006.01) A61K 31/4545 (2006.01) A61K 31/496 (2006.01) A61K 31/5377 (2006.01) A61K 31/551 (2006.01) A61P 3/10 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) A61P 17/06 (2006.01) A61P 19/02 (2006.01) A61P 27/02 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 35/04 (2006.01) A61P 43/00 (2006.01) C07D 313/00 (2006.01) C07D 405/14 (2006.01) C07D 407/06 (2006.01) C12N 1/20 (2006.01) C12P 17/08 (2006.01)

Patent

CA 2494536

Compounds represented by the following general formula (I), pharmacologically acceptable salts thereof or hydrates of the same: (I) wherein W represents (see formula I), (see formula II) or (see formula III) and R3, R7, R16, R17, R20, R21 and R21' are the same or different and each represents hydrogen, etc. Because of inhibiting angiogenesis and inhibiting the production of VEGF particularly in hypoxia, the compounds (I) are useful as remedies for solid cancer.

L'invention concerne des composés représentés par la formule générale (I), leurs sels acceptables sur le plan pharmacologique et leurs hydrates. Dans la formule (I), W représente (1), (2) ou (3) et R?3¿, R<SP>7</SP>, R<SP>16</SP>, R<SP>17</SP>, R<SP>20</SP>, R<SP>21</SP> et R?21'¿ sont identiques ou différents et chacun représente hydrogène, etc. Etant donné qu'ils inhibent l'angiogenèse et la production de VEGF, notamment pour l'hypoxie, les composés (1) conviennent comme remèdes pour le cancer solide.

Affiliated with

Also associated with

Rating

A 12-membered ring macrolide active substance does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with A 12-membered ring macrolide active substance, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and A 12-membered ring macrolide active substance will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1344705