A-21978c cyclic peptide derivatives and their production

Details A-21978c cyclic peptide derivatives and their production A-21978c cyclic peptide derivatives and their production

C - Chemistry, Metallurgy

12

P

195/89, 530/7.08

C12P 21/04 (2006.01) C07K 5/12 (2006.01) C07K 7/54 (2006.01) C07K 7/58 (2006.01) C07K 7/64 (2006.01) C07K 11/02 (2006.01) C12N 9/52 (2006.01) C12P 21/00 (2006.01) C12P 21/06 (2006.01)

Patent

CA 1200777

Abstract of the Invention A-21978C cyclic pep ides of the formula Image Wherein R is selected from the group consisting of hydrogen, an amino-protecting group, 8-methyldecanoyl, 10-methylundecanoyl, 10-methyldodecanoyl, the specific C10-alkanoyl group of A-21978C factor C0 and the specific C12-alkanoyl groups of A-21978C factors C4 and C5; R1 and R2 are, independently, hydrogen or an amino-protecting group, and salts thereof, are prepared by enzymatic deacylation of an antibiotic selected from A-21978C complex, A-21978C factors C0, C1, C2, C3, C4 and C5 and blocked A-21978C complex and factors C0, C1, C2, C3, C4 and C5, using an enzyme produced by the Actinoplanaceae, preferably by Actinoplanes utahensis. These A-21978C cyclic peptides or a pharmaceutically- acceptable salt thereof are useful intermediates for preparing new semi-synthetic antibiotics.

428102

Affiliated with

Also associated with

Rating

A-21978c cyclic peptide derivatives and their production does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with A-21978c cyclic peptide derivatives and their production, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and A-21978c cyclic peptide derivatives and their production will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1185154