A 4-oxo-1- (3-substituted phenyl) -1, 4-dihydro-1,...

Details A 4-oxo-1- (3-substituted phenyl) -1, 4-dihydro-1,... A 4-oxo-1- (3-substituted phenyl) -1, 4-dihydro-1,...

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/4375 (2006.01)

Patent

CA 2626928

The current application is directed to a compound of the structural formula (22), crystal form and crystalline free acid thereof, pharmaceutical compositions comprising these compounds and methods of preparing same These compounds are phosphodiesterase-4 inhibitors and are useful in the treatment of asthma and inflammation and are useful for the enhancement of cognition

La présente invention concerne un composé de formule structurale (22), sa forme cristalline et son acide libre cristallin, des compositions pharmaceutiques comprenant ce composé et des procédés de préparation de ce composé. Ce composé constitue un inhibiteur de phosphodiestérase-4 et est utile pour le traitement de l~asthme et des inflammations, ainsi que pour l~amélioration de la cognition.

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