A-40104 antibiotics and process for production thereof

Details A-40104 antibiotics and process for production thereof A-40104 antibiotics and process for production thereof

C - Chemistry, Metallurgy

07

G

195/112, 260/471

C07G 11/00 (2006.01) C07H 15/18 (2006.01) C12P 1/02 (2006.01) C12P 19/44 (2006.01)

Patent

CA 1135641

Abstract The novel A-40104 antibiotic complex, comprising active factors A, B, C, and D, is produced by the novel submerged aerobic fermentation of the new strain of Clitopilus pseudo-pinsitus NRRL 11179. Individual factors A, B, and C have been isolated. A-40104 factor C is the known antibiotic pleuromutilin. A-40104 factors A and B are novel antibiotics related to pleuromutilin. A-40104 factor A, the major new factor, is the D-xylose acetal derivative of pleuromutilin. A-40104 factors A and B, their 19,20-dihydro derivatives and the per(C2-C6)- alkanoyl derivatives of factors A and B and of their 19,20-dihydro derivatives are active against gram- positive and gram-negative bacteria, anaerobic bacteria, and Mycoplasma.

317427

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