A bacterial atp synthase binding domain

Details A bacterial atp synthase binding domain A bacterial atp synthase binding domain

C - Chemistry, Metallurgy

07

K

C07K 14/35 (2006.01) A61K 31/00 (2006.01) C12N 15/31 (2006.01) C12N 15/52 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2579971

This invention provides an isolated mutant atpE protein and departing from said mutant atpE protein the identification of an ATPase binding domain. This invention also provides related nucleic acids, vectors, host cells, pharmaceutical compositions and articles of manufacture. This invention further provides methods for determining whether a test compound interacts with an atpE protein, i.e. with the ATPase binding domain of the present invention, as well as pharmaceuticals compositions comprising said test compound, in particular as antimicrobials, more particular as antimycobacterial agent, even more particular for treating tuberculosis in a subject.

L'invention concerne une protéine atpE mutante isolée et l'identification d'un domaine de liaison d'ATPase basé sur ladite protéine mutante. Elle concerne également des acides nucléiques, des vecteurs, des cellules hôtes, des compositions pharmaceutiques et des articles associés. Elle concerne, de plus, des méthodes servant à déterminer si un composé d'essai entre en interaction avec la protéine atpE, à savoir, avec le domaine de fixation d'ATPase, ainsi que des compositions pharmaceutiques contenant ledit composé d'essai, en particulier, sous forme d'agent antimicrobien, plus particulièrement, en tant qu'agent antimycobactérien, et encore plus particulièrement, en tant qu'agent servant à traiter la tuberculose chez un individu.

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