A bacterial nitroreductase gene-prodrug system

Details A bacterial nitroreductase gene-prodrug system A bacterial nitroreductase gene-prodrug system

C - Chemistry, Metallurgy

12

N

C12N 15/53 (2006.01) A61K 31/70 (2006.01) A61K 35/76 (2006.01) A61K 38/44 (2006.01) A61K 47/42 (2006.01) C12N 9/02 (2006.01) C12N 15/86 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2175687

The system of the invention comprises: (i) a viral vector comprising a nucleotide sequence encoding a nitroreductase, which nitroreductase in capable of converting a prodrug into a cytotoxic drug; and (ii) a prodrug capable of being converted into a cytotoxic drug by the nitroreductase encoded by the vector.

Le système selon l'invention comprend : (i) un vecteur viral comprenant une séquence nucléotidique codant une nitroréductase, cette nitroréductase étant capable de transformer un précurseur de médicament en médicament cytotoxique; ainsi que (ii) un promédicament qui peut être transformé en médicament cytotoxique par la nitroréductase codée par ledit vecteur.

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