A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61P 25/28 (2006.01) C07K 16/18 (2006.01) G01N 33/577 (2006.01)
Patent
CA 2632822
The present invention is related to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease. The present invention provides novel methods and compositions comprising highly specific and highly effective antibodies having the ability to specifically recognize and bind to specific epitopes from a range of .beta.-amyloid proteins. The antibodies enabled by the teaching of the present invention are particularly useful for the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of diseases and disorders associated with amyloid plaque formation including secondary amyloidosis and age-related amyloidosis including, but not limited to, neurological disorders such as Alzheimer's Disease (AD).
La présente invention concerne des procédés et des compositions d'utilisation thérapeutique et diagnostique dans le traitement de maladies et de troubles causés par des protéines amyloïde ou de type amyloïde ou associés à ces protéines, notamment l'amylose, un groupe de troubles et d'anomalies associés à la protéine amyloïde tels que la maladie d'Alzheimer. Cette invention concerne de nouveaux procédés et de nouvelles compositions comprenant des anticorps hautement spécifiques et hautement efficaces qui ont la capacité de reconnaître et de se lier spécifiquement à des épitopes spécifiques d'une gamme de protéines bêta-amyloïde. Les anticorps validés par les enseignements de cette invention conviennent particulièrement au traitement de maladies et de troubles causés par des protéines amyloïdes ou de type amyloïde ou associés à ces protéines notamment l'amylose, un groupe de maladies et de troubles associés à la formation de plaque d'amyloïdes notamment l'amylose secondaire et l'amylose liée à l'âge, notamment des troubles neurologiques tels que la maladie d'Alzheimer (AD).
Greferath Ruth
Hickman David
Muhs Andreas
Nicolau Claude
Pfeifer Andrea
Ac Immune Sa
Goudreau Gage Dubuc
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