C - Chemistry – Metallurgy – 08 – F
Patent
C - Chemistry, Metallurgy
08
F
C08F 220/00 (2006.01)
Patent
CA 2635469
The invention relates to a biocompatible, non-biodegradable, and non-toxic polymer of formula (I), comprising of three monomeric units, selected from 1- Vinylpyrrolidone (VP), N-Isopropylacrylamide (NIPAM), and ester of Maleic anhydride and Polyethylene glycol (MPEG), cross-linked with a bi-functional vinyl derivative, of high purity and substantially free of respective toxic monomeric contaminants, and a process for preparation thereof. The invention further relates to nanoparticulate pharmaceutical compositions of poorly water- soluble drugs or compounds comprising the polymer of the invention, which are safe, less-toxic and convenient for bedside adminstration to patients in need thereof. Furthermore, the invention relates to a highly selective method for preparation of nanoparticulate pharmaceutical compositions of poorly water- soluble drugs or compounds.
La présente invention concerne un polymère non toxique, non biodégradable, et biocompatible de formule (I), comportant trois unités monomères, choisis parmi 1-Vinylpyrrolidone (VP), N-Isopropylacrylamide (NIPAM), et ester d'anhydride maléïque et de polyéthylène glycol (MPEG), réticulés avec un dérivé vinyle bifonctionnel, de grande pureté et sensiblement exempt de contaminants monomères toxiques respectifs, ainsi que son procédé de préparation. L'invention concerne également des compositions pharmaceutiques à base de nanoparticules de médicaments ou des composés faiblement hydrosolubles comportant le polymère selon l'invention, qui sont surs, moins toxiques et appropriés pour l'administration à des patients qui en ont besoin. L'invention concerne en outre un procédé très sélectif pour la préparation de compositions pharmaceutiques à base de nanoparticules de médicaments ou de composés faiblement hydrosolubles.
Burman Anand C.
Gupta Pawan Kumar
Jaggi Manu
Khattar Dhiraj
Kumar Mukesh
Dabur Pharma Limited
Fresenius Kabi Oncology Limited
Riches Mckenzie & Herbert Llp
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