A biological marker for inflammation

G - Physics – 01 – N

Patent

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G01N 33/564 (2006.01)

Patent

CA 2586773

Inflammatory state in a subject is assayed by determining the level of expression of A3 adenosine receptor (A3AR) in white blood cells (WBC), e.g. circulating WBCs, from the subject. A high level of expression of A3AR is indicative of an inflammatory state in the subject. This assay can be used for determining the severity of inflammation in a subject and monitoring the efficacy of anti-inflammatory treatment. Also, the level of expression may be used for selecting patients to receive an anti-inflammatory treatment that comprises an A3AR agonist.

La détermination du taux d'expression du récepteur d'adénosine A3 (A3AR) dans les leucocytes (WBC), précisément les leucocytes circulants, permet de détecter par dosage biologique un état inflammatoire chez un sujet. Un taux d'expression élevé de l'A3AR indique la présence d'un état inflammatoire chez le sujet. Ce dosage biologique permet de déterminer la gravité de l'inflammation chez le sujet et de surveiller l'efficacité du traitement anti-inflammatoire. Par ailleurs, le taux d'expression peut servir à sélectionner les patients auxquels sera administré un traitement anti-inflammatoire à base d'agoniste A3AR.

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