A bioprocess for the generation of pluripotent cell derived...

Details A bioprocess for the generation of pluripotent cell derived... A bioprocess for the generation of pluripotent cell derived...

C - Chemistry, Metallurgy

12

N

C12N 5/08 (2006.01) C12N 5/00 (2006.01) C12N 5/06 (2006.01) C12Q 1/02 (2006.01)

Patent

CA 2351156

The present inventors identified aggregation of embryoid bodies (EBs) as the cause of the difficulty in generating large numbers of the embryonic stem cells (ES) cell-derived tissues. To counter this, the invention provides a novel bioprocess where aggregation of EBs is physically prevented, such as by an encapsulating matrix, Liquid Suspension Culture- encapsulated (LSCe). As a result, EBs can be cultured in high cell density, well-mixed systems. Well- mixed conditions facilitate measurement and control of the bulk media conditions and allow for the use of scalable bioreactor systems for clinical production of tissue. Therefore, LSCe enables generation of ES cell-derived tissue on a clinical scale. The invention is also applicable to other types of pluripotent cells

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