A buffered, liquid nicotine composition for pulmonary...

A - Human Necessities – 61 – K

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A61K 31/465 (2006.01) A61K 9/08 (2006.01) A61K 9/12 (2006.01) A61K 9/72 (2006.01) A61K 47/02 (2006.01) A61K 47/10 (2006.01) A61K 47/12 (2006.01) A61P 25/34 (2006.01)

Patent

CA 2487699

The composition consists of liquid pharmaceutical formulation comprising nicotine in any form for administration essentially to the lungs. The formulation is acidified and/or alkalized by buffering and/or pH regulation, which provides a tmax of nicotine in arterial blood of a subject within a short period of time after administration. The administration preferably implies spraying an aerosol into the oral cavity for further distribution, essentially to the lungs. A method for manufacturing the formulation is also included, as well as use of the formulation in therapy, e.g. for treating addiction to tobacco.

cette composition est constituée par une préparation pharmaceutique liquide contenant de la nicotine sous une quelconque forme pour administration essentiellement aux poumons. Cette préparation, qui est acidifiée et/ou alcalinisée par tamponnage et/ou régulation du pH, permet d'introduire un t¿max ?de nicotine dans le sang artériel très rapidement après administration. L'administration se fait de préférence par vaporisation d'un aérosol dans la cavité buccale pour distribution plus générale, essentiellement dans les poumons. L'invention porte également sur un procédé de fabrication de la préparation, ainsi que sur l'utilisation thérapeutique de cette dernière, à savoir pour le traitement du tabagisme.

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