A c5a-like seven transmembrane receptor

Details A c5a-like seven transmembrane receptor A c5a-like seven transmembrane receptor

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 9/64 (2006.01) C12N 15/10 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2223038

The present invention provides nucleotide and amino acid sequences that identify and encode a novel C5a-like seven transmembrane receptor (CALR) expressed in human mast cells. The present invention also provides for antisense molecules to the nucleotide sequences which encode CALR, expression vectors for the production of purified CALR, antibodies capable of binding specifically to CALR, hybridization probes or oligonucleotides for the detection of CALR-encoding nucleotide sequences, diagnostic tests based on CALR-encoding nucleic acid molecules, genetically engineered host cells for the expression of CALR, and antagonists and inhibitors of the polypeptide CALR.

L'invention porte: sur des séquences de nucléotides et d'acides aminés identifiant et codant pour un nouveau récepteur à sept transmembranes (CALR), du genre C5a, exprimé dans les mastocytes; sur des molécules antisens des séquences de nucléotides codant pour le CALR; sur des vecteurs d'expression servant à la production de CALR purifié; sur des anticorps capables de se fixer spécifiquement au CALR; sur des sondes d'hybridation ou des oligonucléotides servant à la détection des séquences de nucléotides codant pour le CALR; sur des tests diagnostiques utilisant les molécules d'acide nucléique codant pour le CALR; sur des cellules hôtes produites par génie génétique en vue de l'expression du CALR; et sur des antagonistes et des inhibiteurs du polypeptide CALR.

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