A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01) C12N 15/13 (2006.01)
Patent
CA 2615761
Cytotoxic conjugates comprising a cell binding agent and a cytotoxic agent, therapeutic compositions comprising the conjugate, methods for using the conjugates in the inhibition of cell growth and the treatment of disease, and a kit comprising the cytotoxic conjugate are disclosed are all embodiments of the invention. In particular, the cell binding agent is a monoclonal antibody, and epitope-binding fragments thereof, that recognizes and binds the CA6 glycotope. The present invention is also directed to humanized or resurfaced versions of DS6, an anti-CA6 murine monoclonal antibody, and epitope-binding fragments thereof.
Dans les modes de réalisation, l'invention concerne des conjugués cytotoxiques comprenant un agent de liaison cellulaire et un agent cytotoxique, des compositions thérapeutiques comprenant le conjugué, des méthodes d'utilisation des conjugués pour l'inhibition de la croissance cellulaire et le traitement de maladies, ainsi qu'un nécessaire comprenant le conjugué cytotoxique. En particulier, l'agent de liaison cellulaire est un anticorps monoclonal, ou un fragment de liaison d'épitopes de ce dernier, qui reconnaît et fixe le glycotope CA6. La présente invention concerne également des versions humanisées ou resurfacées de DS6, un anticorps monoclonal murin anti-CA6, ainsi que des fragments de liaison d'épitopes de ce dernier.
Chun Philip
Payne Gillian
Tavares Daniel
Gowling Lafleur Henderson Llp
Immunogen Inc.
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