C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/02 (2006.01) A61K 38/16 (2006.01) A61P 25/28 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2560618
A cell culture system which models in vivo serum amyloid A amyloidogenesis and methods of use of said cell culture system for identifying amyloid modulating compounds are provided. Also provided are compounds and methods for modulating the interaction of an amyloid polypeptide and heparan sulfate and for treating amyloid-associated disease.
Cette invention concerne un système de culture cellulaire in vivo permettant de modéliser l'amyloïdogenèse de l'amyloïde A et des méthodes d'utilisation dudit système de culture cellulaire pour l'identification de composés de modulation amyloïde. L'invention concerne également des composés et des méthodes permettant de moduler l'interaction polypeptide amyloïde-sulfate d'héparan et de traiter des maladies associées aux amyloïdes.
Ancsin John B.
Elimova Elena
Kisilevsky Robert
Queen's University At Kingston
Steeg Carol Miernicki
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