C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 39/104 (2006.01) A61K 48/00 (2006.01) C07K 14/21 (2006.01) C07K 19/00 (2006.01) C12N 15/31 (2006.01) C12N 15/63 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2432731
The invention provides chimeric proteins comprising a non-toxic Pseudomonas exotoxin A sequence and a Type IV pilin loop sequence, wherein the Type IV loop sequence is inserted within the non-toxic Pseudomonas exotoxin A. The invention also provides polynucleotides encoding the chimeric proteins, and compositions comprising the polynucleotides or the chimeric proteins. The invention also provides methods for using the chimeric proteins, polynucleotides and compositions of the invention.
L'invention concerne des protéines chimériques comprenant une séquence d'exotoxine A non toxique de Pseudomonas et une séquence en boucle de piline de type IV, la séquence en boucle de type IV étant insérée dans l'exotoxine A non toxique de Pseudomonas. L'invention concerne également des polynucléotides codant pour les protéines chimériques, et des compositions comprenant les polynucléotides ou les protéines chimériques. L'invention concerne également des méthodes d'utilisation des protéines chimériques, des polynucléotides et des compositions de l'invention.
Sim & Mcburney
The Government Of The United States Of America
LandOfFree
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