A collagen scaffold for cell growth and a method for...

A - Human Necessities – 61 – L

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A61L 27/24 (2006.01) A61F 2/08 (2006.01) A61K 35/32 (2006.01) A61L 27/50 (2006.01)

Patent

CA 2731237

A bioscaffold and method of manufacture is described. The bioscaffold comprised greater than 80% type I collagen fibers or bundles having a knitted structure providing tensile load strength. The method of manufacture comprises the steps of. (a) isolating collagen fibers or bundles; (b) incubating said fibers or bundles in a mixture of NaOH, alcohol, acetone, HCl and ascorbic acid; and (c) mechanical manipulation of said fibers or bundles to produce a knitted structure.

La présente invention concerne un biosupport et son procédé de fabrication. Ce biosupport est constitué à plus de 80 % de fibres ou de faisceaux de collagène de type I présentant une structure maillée assurant une bonne résistance à la traction. Le procédé de fabrication comprend les étapes consistant (a) à isoler des fibres ou des faisceaux de collagène ; (b) à placer en incubation lesdites fibres ou lesdits faisceaux dans un mélange de NaOH, d'alcool, d'acétone, de HCl et d'acide ascorbique ; et (c) à manipuler mécaniquement lesdites fibres ou lesdits faisceaux pour obtenir une structure maillée.

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