A collection and methods for its use

Details A collection and methods for its use A collection and methods for its use

C - Chemistry, Metallurgy

12

N

C12N 15/10 (2006.01) C07K 16/00 (2006.01) C40B 30/02 (2006.01) C40B 40/08 (2006.01) C40B 50/06 (2006.01)

Patent

CA 2758356

The present disclosure enables methods of identifying the VH and VL class pairs in the human immune repertoire, determining the VH and VL class pairs that are most prevalent and those having favorable biophysical properties. More specifical-ly, the collections of the present disclosure comprise the most prevalent and/or preferred VH and VL class pairings with highly di-versified CDRs.

La présente invention concerne des procédés d'identification de paires de domaines VH et VL dans le répertoire immunitaire humain, des procédés de détermination des paires de domaines VH et VL qui sont les plus prévalentes, ainsi que de celles qui présentent les propriétés biophysiques les plus intéressantes. De façon plus précise, les collections de la présente invention comprennent les paires de domaines VH et VL les plus prévalentes et/ou préférées, caractérisées par des régions déterminant la complémentarité hautement diversifiées.

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