A combination kit used in the treatment of malaria

Details A combination kit used in the treatment of malaria A combination kit used in the treatment of malaria

A - Human Necessities

61

K

A61K 31/4706 (2006.01) A61K 31/47 (2006.01)

Patent

CA 2413775

A combination kit for the treatment of malaria caused by Plasmodium vivax (P. vivax) having individual doses of an anti-malarial agent, 3-[1-[[4-[(6-methoxy- 8-quinolinyl)amino]pentyl]amino]ethylidene]-dihydro-2(3H)-furanone (I) in the form of capsules; individual doses of the anti-malarial agent, chloroquine in the form of tablets; and instruction material for the administration of the two anti-malarial drugs. The combination kit is particularly suited for a 6 days treatment regimen where the treatment is rendered by five tablets containing 500 mg of chloroquine phosphate (equivalent to 300 mg base), three to be taken on day one and one each on days two and three; and five capsules containing 25 mg of 3-[1-[[4-[(6-methoxy-8- quinolinyl)amino]pentyl]amino]ethylidene]-dihydro-2(3H)-furanone (I), one each to be taken on days two to six.

La présente invention concerne un kit de combinaison destiné au traitement du paludisme causé par <i>Plasmodium vivax (P. vivax)</i>, présentant des doses individuelles d'un agent antipaludique, 3-[1-[[4-[(6-méthoxy-8-quinolinyle)amino]pentyle]amino]éthylidène]éthylidène]-dihydro-2(3H)-furanone (I) sous forme de gélules, de doses individuelles de cet agent antipaludique, de la chloroquinine sous forme de cachets, et des documents d'instruction relative à l'administration de ces deux médicaments antipaludiques. Ce kit de combinaison est particulièrement adapté pour un traitement de six jours qui consiste en cinq cachets contenant 500 mg de phosphate de chloroquinine (équivalent à une base de 300 mg), trois devant être pris le premier jour et un chacun des deuxième et troisième jour, et cinq gélules contenant 25 mg de 3-[1-[[4-[(6-méthoxy-8-quinolinyle)amino]-dihydro-2(3H)-furanone (I), une gélule devant être prise du deuxième au sixième jour.

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