A complex between folic acid and polysaccharides, its...

C - Chemistry – Metallurgy – 08 – B

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C08B 37/00 (2006.01) A61K 31/715 (2006.01) A61P 35/04 (2006.01) C08B 37/02 (2006.01)

Patent

CA 2407065

This invention relates to a complex between folic acid and polysaccharides and its preparation method, especially relates to a complex between folic acid and dextran, its preparation method and a pharmaceutical composition comprising said complex as active component, and also the use of such complex in anti- tumor. The general formula of the complex is as follows: (X)n-Y, wherein X can be the same or different, and is selected from folic acid and its derivatives or other substances targeting cells through FR of the cell membrane, Y is polysaccharides and n >=1.

L'invention concerne une combinaison d'acide folique et de polysaccharide et son procédé de préparation, plus particulièrement la combinaison d'acide folique et de dextrane, son procédé de préparation, une composition pharmaceutique contenant cette combinaison agissant comme principe actif et l'application de cette combinaison dans le traitement des tumeurs. La combinaison d'acide folique et de polysaccharide est de formule (I) dans laquelle X, identique ou non, est sélectionné dans l'acide folique ou ses dérivés ou encore d'autres récepteurs de l'acide folique sur la membrane cellulaire qui pénètrent la substance cellulaire ; Y désigne un polysaccharide et n>=1.

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