A composition and method for the enhancement of the efficacy...

A - Human Necessities – 61 – K

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Details

A61K 47/36 (2006.01) A61K 31/337 (2006.01) A61K 31/513 (2006.01) A61K 31/519 (2006.01) A61K 31/664 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2370003

The present invention relates to the enhancement of the efficacy of drugs, and more particularly, with overcoming the resistance of cells or organisms to drugs. In particular, the present invention provides a method for enhancing the effectiveness of a cytotoxic or anti-neoplastic agent, comprising the step of co-administering said agent with hyaluronan, wherein co-administration with hyaluronan enhances the agent's cancer cell-killing potential.

Cette invention, qui a trait à l'accroissement de l'efficacité de médicaments, vise plus précisément à surmonter la pharmacorésistance de cellules ou d'organismes. Elle porte, notamment, sur une méthode permettant d'accroître l'efficacité d'un agent cytotoxique ou anti-néoplasique, laquelle méthode consiste à administrer cet agent en association avec du hyaluronan. Administré de concert avec cet agent, le hyaluronan renforce son potentiel de tueur de cellules cancéreuses.

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