A composition comprising an extract of tiarella polyphylla...

A - Human Necessities – 61 – K

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A61K 36/185 (2006.01) A23L 1/29 (2006.01)

Patent

CA 2615641

The present invention relates to a composition comprising an extract of Tiarella polyphylla, and tiarellic acid isolated therefrom having anti- inflammatory, anti-allergic and anti-asthmatic activity. The extract of Tiarella polyphylla and the tiarellic acid isolated therefrom shows the inhibitory effect on the LTC4 release in vitro test and the suppressive effect on the IgE level and the cytokine(IL-4, IL-5 and IL- 13) production, airway hyperresponsiveness, and leukocyte infiltration in OVA-induced asthmatic mice. Therefore, it can be used as the therapeutics or functional health food for treating and preventing inflammatory, allergic and asthmatic disease.

La présente invention concerne une composition comprenant un extrait de Tiarella polyphylla, et de l'acide tiarellique isolé à partir de celui-ci, présentant une activité anti-inflammatoire, anti-allergique et anti-asthmatique. L'extrait de Tiarella polyphylla et l'acide tiarellique isolé à partir de celui-ci présentent un effet inhibiteur sur la libération de LTC4 en test in vitro et un effet suppressif sur le taux d'IgE et la production de cytokine(IL-4, IL-5 et IL- 13), l'hyperréactivité bronchique, et l'infiltration de leucocytes dans une souris asthmatique ayant subi des injections d'OVA. C'est pourquoi ils peuvent être utilises en tant que produits thérapeutiques ou aliments naturels fonctionnels dans le traitement et la prévention de maladies inflammatoires, allergiques et asthmatiques.

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