A composition containing a bisphosphonic acid in combination...

A - Human Necessities – 61 – K

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Details

A61K 31/663 (2006.01) A61K 9/20 (2006.01) A61K 9/48 (2006.01) A61K 31/593 (2006.01) A61P 19/08 (2006.01)

Patent

CA 2671727

The present invention relates to pharmaceutical compositions containing a bisphosphonic acid in combination with a non-activated metabolite of vitamin D for oral administration. The compositions of the invention either do not contain or contain only low concentrations of a glidant. Also provided are methods for preparing such compositions and methods of use thereof, for preventing or treating abnormal bone resorption in mammals.

La présente invention concerne des compositions pharmaceutiques contenant un acide bisphosphonique combiné à un métabolite non actif de la vitamine D, à administration orale. Ces compositions ne contiennent pas d'agent glissant ou alors renferment de faibles concentrations d'un agent glissant. L'invention concerne également des méthodes de préparation de ces compositions et leurs méthodes d'utilisation pour la prévention ou le traitement d'une résorption osseuse anormale chez les mammifères.

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