A composition for accelerating bone fracture healing

Details A composition for accelerating bone fracture healing A composition for accelerating bone fracture healing

A - Human Necessities

61

K

A61K 31/444 (2006.01) A61K 9/10 (2006.01) A61K 9/14 (2006.01) A61K 9/16 (2006.01) A61K 9/19 (2006.01) A61K 31/165 (2006.01) A61K 31/221 (2006.01) A61K 31/27 (2006.01) A61K 31/277 (2006.01) A61K 31/343 (2006.01) A61K 31/381 (2006.01) A61K 31/40 (2006.01) A61K 31/4035 (2006.01) A61K 31/4166 (2006.01) A61K 31/42 (2006.01) A61K 31/422 (2006.01) A61K 31/423 (2006.01) A61K 31/4375 (2006.01) A61K 31/44 (2006.01) A61K 31/4409 (2006.01) A61K 31/4418 (2006.01) A61K 31/4425 (2006.01) A61K 31/4439 (2006.01) A61K 31/445

Patent

CA 2447619

Compositions for promoting healing of bone fracture which contain as the active ingredient a phosphodiesterase (PDE) 4 inhibitor having an effect of inhibiting PDE4. In particular, medicinal compositions containing the PDE4 inhibitor and a biocompatible and biodegradable polymer which exert an excellent effect of promoting quick healing of bone fracture when processed into dosage forms adequate for topical administration to bone fracture sites, for example, microspherical preparations. These compositions are useful in treating bone fracture in, for example, aged persons, patients with diabetics and patients with osteoporosis which can be hardly repaired.

Cette invention concerne des compositions favorisant la guérison d'une fracture osseuse et contenant, comme ingrédient actif, un inhibiteur de la phosphodiestérase-4 ayant pour effet d'inhiber la phosphodiestérase-4. Cette invention concerne plus particulièrement des compositions médicinales contenant l'inhibiteur de la phosphodiestérase-4 ainsi qu'un polymère biocompatible et biodégradable et présentant un excellent effet favorisant une guérison rapide d'une fracture osseuse lorsqu'elles sont traitées en formes dosifiées appropriées à une administration topique dans des sites de fracture osseuse, notamment des préparations microsphériques. Ces compositions servent au traitement de fractures osseuses, notamment chez les personnes âgées, les patients diabétiques et les patients atteints d'ostéoporose pouvant être difficilement réparée.

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