A composition for regenerative treatment of cartilage disease

A - Human Necessities – 61 – K

Patent

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A61K 31/444 (2006.01) A61K 9/10 (2006.01) A61K 9/14 (2006.01) A61K 9/16 (2006.01) A61K 9/19 (2006.01) A61K 31/165 (2006.01) A61K 31/221 (2006.01) A61K 31/27 (2006.01) A61K 31/277 (2006.01) A61K 31/343 (2006.01) A61K 31/381 (2006.01) A61K 31/40 (2006.01) A61K 31/4035 (2006.01) A61K 31/4166 (2006.01) A61K 31/42 (2006.01) A61K 31/422 (2006.01) A61K 31/423 (2006.01) A61K 31/4375 (2006.01) A61K 31/44 (2006.01) A61K 31/4409 (2006.01) A61K 31/4418 (2006.01) A61K 31/4425 (2006.01) A61K 31/4439 (2006.01) A61K 31/445

Patent

CA 2447618

Therapeutic compositions for repairing chondropathy which contain as the active ingredient a phosphodiesterase (PDE) 4 inhibitor having an effect of inhibiting PDE4. In particular, medicinal compositions containing the PDE4 inhibitor and a biocompatible and biodegradable polymer which exert an excellent effect of repairing cartilage when processed into dosage forms adequate for topical administration to sites suffering from chondropathy, for example, microspherical preparations.

Cette invention concerne des compositions thérapeutiques permettant de réparer la chondropathie et contenant, comme ingrédient actif, un inhibiteur de la phosphodiestérase-4 ayant pour effet d'inhiber la phosphodiestérase-4. Cette invention concerne plus particulièrement des compositions médicinales contenant l'inhibiteur de la phosphodiestérase-4 ainsi qu'un polymère biocompatible et biodégradable et présentant un excellent effet de réparation du cartilage lorsqu'elles sont traitées en formes dosifiées appropriées à une administration topique dans des sites atteints de chondropathie, notamment des préparations microsphériques.

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