A composition for selective serotonin reuptake inhibition...

A - Human Necessities – 61 – K

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Details

A61K 31/702 (2006.01) A61K 35/23 (2006.01) A61P 25/24 (2006.01)

Patent

CA 2677872

The present invention relates to a novelsynergistic pharmaceutical composition for serotonin reuptake inhibition, wherein thesaid composition comprises pentacyclic terpenoid glycosides, preferably asiaticoside and madecassoside optionally along with excipients. Also the present invention relates toexcipients; a process of preparation of novelsynergistic pharmaceutical composition for serotonin reuptake inhibition, wherein the process comprising steps of: (a) obtaining extract from the plant Centella asiatica; (b) treating the extract with the solvents to remove fatty substances, chlorophyll and other colorants; (c) purifying the extract through HPLC to obtain the eluted solvent; and (d) concentrating the eluted solvent to arrive at the composition. The invention also relates to thecomposition; and use of a composition comprising pentacyclic terpenoid glycosides, preferably asiaticoside and madecassoside optionally along with excipients to manufacture a medicament for serotonin reuptake inhibition in a subject in need thereof.

Cette invention concerne une nouvelle composition pharmaceutique synergique pour l'inhibition du recaptage de la sérotonine. Cette composition comprend des glycosides de terpenoïde pentacycliques, de préférence, asiaticoside et madecassoside éventuellement avec des excipients. Cette invention concerne également des excipients; un procédé permettant de préparer cette nouvelle composition pharmaceutique synergique pour le recaptage de la sérotonine. Ce procédé comprend les étapes qui consistent: (a) à obtenir un extrait à partir de la plante Centella asiatica; (b) à traiter l'extrait avec des solvants afin d'éliminer les substances grasses, la chlorophylle et d'autres colorants; (c) à purifier l'extrait par CLHP afin d'obtenir le solvant élué, puis (d) à concentrer le solvant élué de manière à obtenir la composition. Cette invention concerne également la composition ainsi que l'utilisation d'une composition comprenant des glycosides de terpenoïde pentacycliques, de préférence, asiaticoside et madecassoside éventuellement avec des excipients pour fabriquer un médicament destiné à inhibition du recaptage de la sérotonine chez un sujet qui le nécessite.

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