A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/06 (2006.01) A61K 31/198 (2006.01) A61K 31/427 (2006.01) A61K 45/00 (2006.01) A61P 25/16 (2006.01) A61P 43/00 (2006.01) C07K 5/097 (2006.01)
Patent
CA 2420537
A compound represented by the formula: (see formula I) wherein A is thiazolyl or the like, X is a bond or the like, m is an integer of 0 to 4, Y is optionally substituted alkyl or the like, Z is a substituent represented by the formula: (see formula II) wherein R3 is hydrogen atom or the like, R4 and R5 are each independently hydrogen atom or the like, W is -(CH2)n- (n is 0,1,2 or 3) or the like, a prodrug thereof, its pharmaceutically acceptable salt, or its solvate is useful as a composition for prevention or treatment of Parkinson's disease.
L'invention concerne des composés de formule générale (1), ou des promédicaments, sels pharmaceutiquement acceptables, ou solvates des composés considérés, utiles comme agents thérapeutiques ou préventifs contre la maladie de Parkinson. Dans ladite formule, A est thiazolyle ou autre, X est une liaison unique ou autre, m est un entier valant entre 0 et 4, Y est alkyle éventuellement substitué ou autre, et Z est un groupe de formule générale (2). Dans cette formule, R?3¿ est hydrogène ou autre, R?4¿ et R?5¿ sont chacun indépendamment hydrogène ou autre, et W est -(CH¿2?)¿n?- (sachant que n vaut 0, 1, 2 ou 3) ou autre.
Koike Katsumi
Shinohara Shunji
Mccarthy Tetrault Llp
Shionogi & Co. Ltd.
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