A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01)
Patent
CA 2629881
The invention relates a compound comprising (a) a peptide and (b) a carrier, wherein said peptide having at least the motif X-X-X-X-X-X-X, wherein at least one amino acid residue X is glycosylated, said peptide being linked to the peptide binding protein and said carrier comprises at least a MHC binding motif being linked to said peptide as well as pharmaceutical compositions comprising said compound and the use of said compound or pharmaceutical composition for the treatment of a disease, such as an inflammatory joint disease. The subject matter of the application is exemplified with peptides derived from type II collagen such as peptides having at least the sequence AGFKGEA, or IAGFKGEQPKG, or the peptide AAAKAAA. Preferably a hydroxylysine in the peptides are glycosylated.
L~invention concerne un composé comprenant (a) un peptide et (b) un vecteur, ledit peptide possédant au moins le motif X-X-X-X-X-X-X, dans lequel au moins un résidu acide aminé X est glycosylé ; de plus, ledit peptide est lié à la protéine de liaison peptidique et ledit vecteur comprend au moins un motif de liaison MHC se trouvant lié au dit peptide. L~invention concerne également des compositions pharmaceutiques comprenant ledit composé et l~utilisation dudit composé ou des dites compositions pharmaceutiques pour traiter une maladie telle que l~inflammation articulaire. L~invention est illustrée par des peptides dérivés de collagène de type II, par exemple des peptides comportant au moins la séquence AGFKGEA, ou la séquence IAGFKGEQPKG, ou le peptide AAAKAAA. Une hydroxylysine est de préférence glycosylée dans lesdits peptides.
Dzhambazov Balik
Holmdahl Rikard
Kihlberg Jan
Vestberg Mikael
Holmdahl Rikard
Ridout & Maybee Llp
LandOfFree
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