G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/53 (2006.01) G01N 33/48 (2006.01) G01N 33/487 (2006.01) G01N 33/50 (2006.01) G01N 33/566 (2006.01) G01N 33/74 (2006.01) G01N 35/00 (2006.01)
Patent
CA 2156834
A method for improved measurement of a concentration of an analyte in a sample having an unknown concentration of the analyte includes using an affinity assay having an experimental indicator. Standard and control samples, each having a known concentration of the analyte, are assayed and a response, an amount of experimental indicator emitted for each sample, is detected. The unknown sample is also assayed and its response is detected. A prior probability density is supplied for the unknown concentration, along with a model for a standard curve relating an expected response to a concentration of the analyte. A posterior density, having a median, for the unknown concentration is generated based on the supplied prior density, the supplied model, and the responses for the standard samples, the control samples and the unknown samples, by applying Bayes' rule. The median of the posterior density may be provided as the measure of concentration of analyte in the unknown sample, with an accuracy defined by the standard deviation of the posterior density. The standard curve preferably accounts for relative error due to experimental variation by using a random variable to represent variations on the analyte concentration scale due to variability in the preparation of samples in the laboratory. The minimal detectable dose for a single assay run may also be determined.
Brown Emery N.
Skates Steven J.
Swabey Ogilvy Renault
The General Hospital Corporation
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