C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 19/00 (2006.01) A61K 47/48 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01) C07K 14/31 (2006.01) C07K 16/30 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2194673
A conjugate comprising (a) a biospecific affinity counterpart (target-seeking group) that binds to a predetermined structure and (b) a peptide that (i) contains an amino acid sequence that is derived from a superantigen, and (ii) has the ability of binding to a V.beta. chain of a T-cell receptor, and (iii) has a modified ability to bind to a MHC class II antigen compared to the superantigen from which the peptide is derived, which parts are covalently linked together.
Conjugué comportant (a) un homologue d'affinité biospécifique (groupe chercheur de cible) se liant à une structure prédéterminée; et (b) un peptide qui (i) contient une séquence d'acides aminés dérivée d'un superantigène, (ii) peut se lier à la chaîne V beta d'un récepteur de lymphocytes T, et (ii) présente une aptitude modifiée à se lier à un antigène HL-A de classe II, par rapport au superantigène dont est dérivé le peptide, ces parties étant liées l'une à l'autre de manière covalente.
Abrahmsen Lars
Bjork Per
Dohlsten Mikael
Kalland Terje
Active Biotech Ab
Pharmacia Aktiebolag
Ridout & Maybee Llp
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