C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 17/08 (2006.01) A61K 38/18 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07K 1/107 (2006.01) C07K 1/18 (2006.01) C07K 14/515 (2006.01)
Patent
CA 2675231
A medicament useful for treating tumors or angiogenesis mediated diseases, medical compositions and kits comprising the medicament and a method for preparing the medicament are provided. The medicament contains complexes of a modifier and angiostatin or its fragments, which have longer in vivo half-life than non-modified angiostatin or its fragments. The modifier is selected from high molecular polymers, proteins or their fragments, polypeptides, small molecules and any other type of compounds.
L'invention porte sur un médicament utile pour le traitement de tumeurs ou de maladies à médiation par l'angiogenèse, sur des compositions médicamenteuses et des kits comprenant le médicament, ainsi que sur un procédé de préparation du médicament. Le médicament contient des complexes d'un modificateur et d'angiostatine ou de ses fragments, qui ont une demi-vie in vivo plus longue que l'angiostatine non modifiée ou ses fragments. Le modificateur est choisi parmi les polymères de masse moléculaire élevée, les protéines ou leurs fragments, les polypeptides, les petites molécules et tout autre type de composés.
Chang Guodong
Fu Yan
Gao Lei
Luo Yongzhang
Yang Shuling
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Protgen Ltd.
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