A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/22 (2006.01) A61K 38/26 (2006.01) A61K 38/28 (2006.01) A61K 47/48 (2006.01)
Patent
CA 2678646
Compositions containing a therapeutic peptide covalently linked to Vitamin B12 at the 5'-hydroxyl group of the ribose moiety of .alpha.-ligand are described. The length of the linkage is optimized so that the biological activity of both the Vitamin B12 and the therapeutic peptide is maintained. Therapeutic peptide includes insulin, PYY, NPY and GLP-1. Attachment to Vitamin B12 provides uptake of the therapeutic peptide from the digestive tract and longer residence time.
L'invention concerne des compositions contenant un peptide thérapeutique, lié de manière covalente à la vitamine B12 sur le groupe 5'-hydroxyle de la partie ribose du ligand .alpha.. La longueur de la liaison est optimalisée de façon à conserver l'activité biologique de la vitamine B12 et du peptide thérapeutique. Le peptide thérapeutique comprend l'insuline, PYY, NPY et GLP-1. L'attachement à la vitamine B12 procure l'absorption du peptide thérapeutique depuis le tractus digestif et un temps de séjour plus long.
Fetherstonhaugh & Co.
Syracuse University
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