A continuous process of preparing intermediate for non-ionic...

Details A continuous process of preparing intermediate for non-ionic... A continuous process of preparing intermediate for non-ionic...

C - Chemistry, Metallurgy

07

C

C07C 231/12 (2006.01) C07C 237/46 (2006.01) A61K 49/00 (2006.01) C07C 231/22 (2006.01)

Patent

CA 2710573

This invention relates to an improved method for the synthesis of 5-amino-N,N'- bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (Compound B), an intermediate in the industrial preparation of non-ionic X-ray contrast agents. In particular, it relates to a continuous process of the iodination reaction followed by the purification of Compound B.

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